############################# Gap open 100 (maximum) [GEP def: 6.66] CLUSTAL W (1.83) multiple sequence alignment Cow -TTCGGGTATACATAATATTTACCTCTTAGGTGCTCTGGAAAAAATGAAGTTTAAAACTC 59 Dog ------AGGTACTCATGTCTCCTTCTGTAATCGCTCTAGGGAAAATGATGTTCAGAAGTC 54 Human -----------ACAAGACATCTCTCTGTAGTTATTCTAGAGAAAATGCAGTTTATAATTT 49 Chimp ----------CACAAGACATCTCTCTGTAGTTATTCTAGAGAAAATGCAGTTTATAATTT 50 Mouse ---GAAATACAGCAAGGATTCTCACTGTTGCTGCTCAAGACAGAATAGAGTTGAGAACTC 57 Rat ATCTACATTGTCTCAAAGAATTCAAGCTTGGTTCTTAAACATTTCTGTAGCTGAGAACTC 60 Chicken -------------------------TATTACCCAAAGATGCATTTAAAAACAACTGAAGC 35 Xenopus -----------------------------ACTGCTAATATATTATAAGTAATGTGTATTG 31 Zebrafish --------------------------AATGGGGTATTTCGGCATTCAAATTTTGCCACGT 34 * Cow ACCAGGTTATAA---ACATTCTGGAAACAAGACTAGGTTTCTCTTTATGGAAGTAAGTGT 116 Dog ACCAGGTTCTAG---ATATTCTAGAAGCAGGACTAAGTATCTCTTTAAGGAAGTGAGAGC 111 Human ACCAGGCAGTAGTAAACATTCTAGAATCAGTACTAAGTTTCTCTTTATGGAAGTAAACAT 109 Chimp ACCAGGCTGTAGTAAACATTCTAGAAGCAGTACTAAGTTTCTCTTCATGGAAGTAAACAT 110 Mouse ATCAACCTATAA---CCATTTTGTGGACAGAACTTTGTCTTTCCTTACAGGAACAAACAT 114 Rat ATCAGCCTATAA---CCATTTTGTGAACAGAACTTT-TCCCTCCTTACAGGGATAAATAT 116 Chicken ACTTCTGGTCCATTCCAACAATTAACAATTGTTGCTGAGCATCTCAGTATTGAAAAGTTG 95 Xenopus ACTGTGTATACAGGGTTTGTCTATGAAGATTCTCATTTCCCTACATTCATATACACATCT 91 Zebrafish TATCTATGTGGGTTGAGTTTAGAGGTAACTTGATGTCTTTGCAAATCATAAATCAACAAC 94 Cow ACTGTCTTGATAGTCTTATCAGAAAAAAAAAAAAAAAGTAGTTGCTCTCCTGCAAAGGGG 176 Dog ATCATCTTGATACTCTTGTCTGAAAAGAGTAAA---AGTAGCTGCTTTTCTACAGAGGGA 168 Human GCCATCTTGATACACTTATTATTCGAAGAAGCAAAAGTAGATACGTTCTTACAGAAGGCA 169 Chimp GCCATCTTGATACACTTATTATTCGAAGAAGCAAAAGTAGATACGTTCTTACAGAAGGCA 170 Mouse TTTACTTTGCTATTATTATTACCTGAAAAACTCAGAGTAGCTGTTTTCCCTACAAAAGGA 174 Rat ATTACTTTGCTATTATTATTACCTGAAAAACTCAGCGTAGCTGTTTTCCCTACAAATG-A 175 Chicken TAGAATTTAGTTTAAAGTAAAAAAGCTGATTGTATATTTTTATTTTTTGTCAAATAGGAA 155 Xenopus GCCATTGTCCTCCCATCAATTCCACTATTAAACTAGTAAAATGATTTGTAGCTATAGATA 151 Zebrafish AGATCATGTACATCTAATTTAATTCACTTTGAAAATGCAAATGCAGTGCTGGTGTGAACA 154 Cow AAAGTTTTTTTGCCAAGTGAAGTGAAAATTT--------TACTCTCTGGTTTTTCCCACA 228 Dog AAAATATTTTTGCCCAGTGAAGTGAAATATTA------CTACTCTCTGCTTCTTCCCACA 222 Human AAAAAAAAAAAATTTTGCTAAGTGAAGTAAAAAATGTACTACTCTCTGCTTCTTCCCACA 229 Chimp AAAAAAATTTT-TTTTGCTAAGTGAAGTAAAAAATGTACTACTCTCTGCTTCTTCCCACA 229 Mouse AGACAACATTT---TTGTCCAGTGAAGTGAAAAATATACTAGCTGCTGCTTCTCCCCACT 231 Rat AGAAAGCATTT---TTGCCCAGTGAAGTGAAAAATATACTAGCCACCGCTTCTTCCCACT 232 Chicken ACAAATAATTACTCTAGCAGAGAGGAGAAATAAGCCAATGTAACTTCTTGCAAAATAATC 215 Xenopus AAAACCTTTTGGTTCAGATTTGTTTTGTTTTTTAAACTGAAGTTGCGCTTTTGCAGAGTA 211 Zebrafish CAAATTATTATGCTTAAATTTAAAGAGATAGTTCACCCTAAAATTAAAATGTACTCACTG 214 * Cow ATAGCCATAAATACGCTGAGGCTGTT-ATTTTGCAAGATGGTTTTTGAGACCCTGC---T 284 Dog GTATCCATAAATATGCTGAGGCTGTTTATTTTGCCAGATGGTTTTTGAGACCCCGC---T 279 Human GTATCCATAAATATGCTGAGGCCGTTTATTTTGCCAGATGGGTTTTGAGACCCTGC---T 286 Chimp GTATTCATAAATATGCTGAGGCCGTTTATTTTGCCAGATGGGTTTTGAGACCCTGC---T 286 Mouse ATATCCATGAAAATGCTGAGGCTGTTTATTTTGCCAGATGAGTTTTGATATTCCCCCACT 291 Rat ATATCCATAAAAATGCTGAGGCTGTTTATTTTGCCAGATGCGTTTTGATATGCCCC-ACT 291 Chicken AAAAAGTGCCATTTTCTTCTCCTGTTTTCTTCCCACAACCTTTGTAAATATTCTGAGACT 275 Xenopus ATGCAATCGGCTGGATGCAATTCTGTTTCCCATCCGCAGATGTGCTGATTGTGTGTTTAC 271 Zebrafish TTTACTCACGACAAGTTTCTTTCTTCTGCTAAACACAAAAGAAGATAATTGAAGAAAGCT 274 * * * Cow GAAAGGAGAGAAGCCCTCGTATTAGATTTCCCTCAAATTCTACCACAAACCACACTTCTC 344 Dog GAAATGAGAGATGCCCTCATTTTATATTTCCCTCAAATTCTACCACAAACCACACTTTCT 339 Human GAAACAAGAGATGCTCTCAT-TTATATTTCCCTCAAATTCTACCACAAACCACACTCGGG 345 Chimp GAAACAAGAGATGCTCTCAT-TTATATTTCCCTCAAATTCTACCACAAACCACACTCGGG 345 Mouse GAAAGTAGAGATGCCTTCATTTTCCATTTCCCTCAGATTCTGCCACAAACCACACTTAGG 351 Rat GAAACTAGAGATGCCCTAATTTTCCATTTCCCTCAGGTTCTGCCACAAACCACACGTACG 351 Chicken GTGTTTATATGAAGATGCAGTTTCAGAGACCACAGTGAAACAACAGATGCCTAAACCACA 335 Xenopus TTAAAGATTTCCTTACAAAAGGCACACATTTCTCTCTCTCTCTTCTCTGCCACAAACCAT 331 Zebrafish GAAAACCTGTAACCATCGACTTCCATAACACTTGTTTTTTTCTACTATGAAAGTCAGTGG 334 Cow GGGAGG------AAAAAAAAAGGCGCAATGTAAGCATGTTTACCTTTAACTGACTAGGAA 398 Dog TGGGAGGAAAAAAAAAAAAAAGTCGCCATGTAAGCATGTTTACCTTCAATAGACTAGGAA 399 Human AGGGAA-------AAGAAAAAGTCGCCACGTAAGCATGTTTACCTTCAAGTGACTAGGAA 398 Chimp AGGGAA-------AAGAAAAAGTCGCCACGTAAGCATGTTTACCTTCAAGTGACTAGGAA 398 Mouse AAGAAA-----------AAAAAATACCATGTAAGCATGTTTACCTTCGCCTCACTAGGAA 400 Rat AA--AA-----------AAAAAATACCACGTAAGCATGTTTACCTTCGACTCACTAGGAA 398 Chicken GAGCTGGGGAGGAAAGAAAAAGTGGCCGTCTAAGCATGTTTACTTGCAGGGACAAGGAAG 395 Xenopus AATGTCCTGTAAGAGGAATAAGCAGGAATCATATTTACCATCTACTGACTCGGACTATTT 391 Zebrafish TTGGAG--------GTTTCCAGCTTTCTTTAAAATATCTTCTGTGTTAAACAAGTGAAAC 386 * * Cow GTTGAAACTTGTC--CATAACTGATGACTCACCACAGTAGGTCTATAAAAGTAAAGGTAC 456 Dog GCGGGAACTTGTC--CATAAAGGATGAGTCACCACTGCAGGTCTATAAAAGTAAAGGTGC 457 Human GTGGAAACCTATC--CATAAGTGATGACTCACCATTGCAGGCCTATAAAAGTAAAGGTAA 456 Chimp GTGGAAACCTATC--CATAAGTGATGACTCACCATTGCAGGCCTATAAAAGTAAAGGTAA 456 Mouse GTTAACACACACC--CCAAAGTGGTGACTCATCACTATCATGCTATAAAATAGAAGATGC 458 Rat GTGAACACCCCCCACCCCAAGTGGTGACTCATCACTATTGCTCTATAAAATAGAGAATGC 458 Chicken TTCTAACTTGTCC---CTAAGTGGTGACTCACTGGAGCAGGGCTATAAATGTAAAGGTAA 452 Xenopus TTTTTTTTTCATGACTCCAGGAGGTGACTCATGGCTCTCGGGGCTATAAAGAGAGCTCAG 451 Zebrafish ATGTTTGGATGAAGGAATAAATAATGACATTTCATTTTTGGGTGAACTATCCTTTAACAG 446 * *** * Cow TTGTCTGGGAAAAGACAGCTGCCTCCAGGCGGATCGTCCAAGATG--------- 501 Dog TTGTCTGGGAGA-GACAGCAGGCTCCAGGCACAACCACCAAGATG--------- 501 Human TCTCTGCGGAAAGACAACAGTCCCCAGGCATCACCATTCAAGATG--------- 501 Chimp TCTCTGCGGAAAGACAACAGTCCCCAGGCATCACCATTCAAGATG--------- 501 Mouse TTGCCCTGGGAAGGAGAGACTCCAGGCACTGCTGGGCACCATG----------- 501 Rat TTGCCCTGGGAAGGAGAGACTCCAGGCACTGCTGGGCACCATG----------- 501 Chicken CTGCTCTCTAAGACATCTGGGCTTCAGACTTCACAAATTCAACATAATG----- 501 Xenopus CCATACCATGAACACTTATTAGTCTTGGAGAGTACTAAAGCCAAGCATG----- 500 Zebrafish GTATTTGAACGGGCTTTAACTGTGATCTGCTGTTTCAGAAGGAAAGCAAACATG 500