Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. RID: 1048697323-026241-3230 Query= THC1259113.prot (1127 letters) Database: Non-redundant SwissProt sequences 122,971 sequences; 44,872,980 total letters If you have any problems or questions with the results of this search please refer to the BLAST FAQs Taxonomy reports
RID: 1048697323-026241-3230
Query= THC1259113.prot (1127 letters)
Database: Non-redundant SwissProt sequences 122,971 sequences; 44,872,980 total letters
If you have any problems or questions with the results of this search please refer to the BLAST FAQs
Taxonomy reports
Score E Sequences producing significant alignments: (bits) Value gi|130228|sp|P10688|PID1_RAT 1-phosphatidylinositol-4,5-bis... 463 e-130 gi|23396799|sp|Q8R3B1|PID1_MOUSE 1-phosphatidylinositol-4,5... 454 e-128 gi|130223|sp|P10687|PIB1_RAT 1-phosphatidylinositol-4,5-bis... 278 4e-75 gi|130226|sp|P10686|PIG1_RAT 1-phosphatidylinositol-4,5-bis... 196 4e-50 gi|130230|sp|P24135|PIG2_RAT 1-phosphatidylinositol-4,5-bis... 178 7e-45 gi|12643487|sp|Q9QW07|PIB4_RAT 1-phosphatidylinositol-4,5-b... 160 1e-39 gi|1730574|sp|P51432|PIP3_MOUSE 1-phosphatidylinositol-4,5-... 158 7e-39 gi|3024409|sp|Q62077|PIG1_MOUSE 1-phosphatidylinositol-4,5-... 90 3e-18 Alignments
Score E Sequences producing significant alignments: (bits) Value gi|130228|sp|P10688|PID1_RAT 1-phosphatidylinositol-4,5-bis... 463 e-130 gi|23396799|sp|Q8R3B1|PID1_MOUSE 1-phosphatidylinositol-4,5... 454 e-128 gi|130223|sp|P10687|PIB1_RAT 1-phosphatidylinositol-4,5-bis... 278 4e-75 gi|130226|sp|P10686|PIG1_RAT 1-phosphatidylinositol-4,5-bis... 196 4e-50 gi|130230|sp|P24135|PIG2_RAT 1-phosphatidylinositol-4,5-bis... 178 7e-45 gi|12643487|sp|Q9QW07|PIB4_RAT 1-phosphatidylinositol-4,5-b... 160 1e-39 gi|1730574|sp|P51432|PIP3_MOUSE 1-phosphatidylinositol-4,5-... 158 7e-39 gi|3024409|sp|Q62077|PIG1_MOUSE 1-phosphatidylinositol-4,5-... 90 3e-18
>gi|130228|sp|P10688|PID1_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III) Length = 756 Score = 463 bits (1192), Expect = e-130 Identities = 276/754 (36%), Positives = 416/754 (55%), Gaps = 31/754 (4%) Query: 140 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 196 + ++++GS+L KV+S+S R++ L D +++ W+ S+K E I+ I+EVR Sbjct: 19 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 77 Query: 197 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 256 G T+ + I ED FS+++ + +LDL+A S A WV GLR +I + + Sbjct: 78 GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSG-S 134 Query: 257 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 316 +D + Q W+ + D + + ++ LN + F+E Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFREC- 188 Query: 317 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 375 D + T+ ++E IE F+++ T R EI + + + E L + L+ FL+ +Q Sbjct: 189 ---DHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEE 245 Query: 376 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 435 ++L +I +YEPS+ + + ++ DGF YL+S D F H++V QDM QPLSHY Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHY 305 Query: 436 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 495 ++SSHNTYL+EDQ GPS YIRAL GCR +ELD WDGP+ EP+IY G+T TS+I+ Sbjct: 306 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365 Query: 496 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 555 F V+ I YAF AS YP+IL LENHCS+ +LG L + + L Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPILLDQPLDGVTTSL 425 Query: 556 PSPD-----VXXXXXXXXXXXXSSNCSGVEG-DVTDEDEGAEMSQRMGKENME-QPNNVP 608 PSP+ + + +G E DV+DE E AEM + ++ +P Sbjct: 426 PSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEVEAAEMEDEAVRSQVQHKPKE-- 483 Query: 609 VKRFQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNY 667 + +L ELS+++ CKSV F F Q ++E+ SF+E A + E+ FV + Sbjct: 484 -DKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRH 542 Query: 668 NKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYV 727 N L+R++P+ R DSSN +P + W GCQIVA+NFQTPG MD+ +G F+ NG CGYV Sbjct: 543 NVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYV 602 Query: 728 LRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEI 787 L+PA +R+ + F++ P P+ L ++IISGQ PK + K +VDP V VEI Sbjct: 603 LKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPKVNKN--KNSIVDPKVIVEI 660 Query: 788 HGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYT 846 HG+ D ++T + NG P +D FEF++ +P+LA+VRF+V D D ++FIGQ T Sbjct: 661 HGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQST 720 Query: 847 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880 IP+ L+ GYRHV L S G+ A+LFV ++I Sbjct: 721 IPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISI 754
>gi|23396799|sp|Q8R3B1|PID1_MOUSE 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III) Length = 756 Score = 454 bits (1169), Expect = e-128 Identities = 275/751 (36%), Positives = 411/751 (54%), Gaps = 25/751 (3%) Query: 140 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 196 + ++++GS+L KV+S+S R++ L D +++ W+ S+K E I+ I+EVR Sbjct: 19 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 77 Query: 197 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 256 G T+ + I ED FS+++ + +LDL+A S WV GLR +I + Sbjct: 78 GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSPADVQHWVQGLRKIIDRSG-S 134 Query: 257 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 316 +D + Q W+ + D + + ++ LN + S F+E Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKEVKDFLKELNVQVDDSYARKIFREC- 188 Query: 317 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 375 D + T+ ++E IE F+ + T R EI + + + E L + L+ FL+ +Q Sbjct: 189 ---DHSQTDSLEDEEIETFYRMLTQRVEIDRAFAEAAGSAETLSVEKLVTFLQHQQREEE 245 Query: 376 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 435 ++L +I +YEPS+ + + ++ DGF YL+S D F H++V QDM QPLSHY Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMNQPLSHY 305 Query: 436 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 495 ++SSHNTYL+EDQ GPS YIRAL GCR +ELD WDGP+ EP+IY G+T TS+I+ Sbjct: 306 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365 Query: 496 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 555 F V+ I YAF AS YP+IL LENHCS+ +LG L + + L Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSL 425 Query: 556 PSPD--VXXXXXXXXXXXXSSNCSGVEG-DVTDEDEGAEMSQRMGKENMEQPNNVPVK-R 611 PSP+ G G + TD + E ++ + Q + P + + Sbjct: 426 PSPEQLKEKILLKGKKLGGLLPAGGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDK 485 Query: 612 FQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 670 +L ELS++V CKSV F F S Q ++E+ SF+E A + E+ FV +N Sbjct: 486 LKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVG 545 Query: 671 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 730 L+R++P+ R DSSN +P + W GCQIVA+NFQTPG MD+ +G F+ NG CGYVL+P Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKP 605 Query: 731 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 790 A +R+ + F++ P +P+ L + IISGQ PK + K +VDP V VEIHG+ Sbjct: 606 AFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKN--KNSIVDPKVIVEIHGV 663 Query: 791 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTIPF 849 D A ++T + NG P +D FEF + +P+LA+VRF+V D D ++FIGQ TIP+ Sbjct: 664 GQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPW 723 Query: 850 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880 L+ GYRHV L S G++ A+LFV ++I Sbjct: 724 NSLKQGYRHVHLLSKNGDLHPSATLFVKISI 754
>gi|130223|sp|P10687|PIB1_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (Phosphoinositide phospholipase C) (PLC-beta-1) (Phospholipase C-beta-1) (PLC-I) (PLC-154) Length = 1216 Score = 278 bits (712), Expect = 4e-75 Identities = 232/800 (29%), Positives = 369/800 (46%), Gaps = 84/800 (10%) Query: 141 NSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNT 200 +S+ +G++ K +S I +L D Q + + ++ E +D+ +K+ R GK+ Sbjct: 20 DSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHA 78 Query: 201 DIFRSNGISDQIS-------EDCAFSVIYGE---NYESLDLVANSADVANIWVTGLRYLI 250 + + + + E +V+YG N L+LVA +VA W + L Sbjct: 79 KAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLA 138 Query: 251 SYGKHTLDMLESSQDNMRTSWVSQMFS--EIDVDNLGHITLCNAVQCIRNLNPGLKTSKI 308 + ++L +Q+ R +++ + ++ ++ V G I L N R + K + Sbjct: 139 T------NLL--AQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIY---RLFSADRKRVET 187 Query: 309 ELKFKELHKSKDKA--GTEVTKEEFIEVFHELCTRPEIYFLLVQF-SSNKEFLDTKDLMM 365 L+ L S++ + + T + + + LC RPEI + +F + +K +L +M Sbjct: 188 ALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMD 247 Query: 366 FLEAEQGVAHINE--------EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF 417 F+ +Q +NE E +I KYEP+ +KG +S+DGF YL + + Sbjct: 248 FINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLSGEENGVV 307 Query: 418 DPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDG 477 PE + +DM QPLSHYFINSSHNTYL Q G S + Y + L GCR VELD W G Sbjct: 308 SPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKG 367 Query: 478 --PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHC-SIXXXXXXXXX 534 + EPVI G TMT++I F+ VI+ I + AF S +P++L ENH S Sbjct: 368 RTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEY 427 Query: 535 XXXLLGDKLYTTS----PNVEESYLPSP-DVXXXXXXXXXXXXSSNCSGVEGDVTDEDEG 589 + GD L P LPSP D+ + G E Sbjct: 428 CRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQAS 487 Query: 590 AEMSQRMGKENMEQP-------NNVPVKRFQLCKELS--------------ELVSICKSV 628 S P + CK+ S E+ ++ + Sbjct: 488 NTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYI 547 Query: 629 Q---FKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSS 685 Q F+ F+ S + K +E+ SF E + ++P +FV YNK L+R++P R+DSS Sbjct: 548 QPVKFESFETSKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSS 607 Query: 686 NMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTK 745 N PQ FW GCQ+VA+NFQT L M +N+G + NG GY L+P MR F T+ Sbjct: 608 NYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTE 667 Query: 746 DSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKTVH 803 V G+ L +KIISGQ K V YV V++ G+P D + +TKT Sbjct: 668 GIVDGIVANTLSVKIISGQFLSDKK--------VGTYVEVDMFGLPVDTRRKAFKTKTSQ 719 Query: 804 QNGDAPIFDES---FEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVP 860 N P+++E F+ ++ LP LA +R ++ G +FIG +P + ++ GY ++ Sbjct: 720 GNAVNPVWEEEPIVFK-KVVLPSLACLRIAAYEE---GGKFIGHRILPVQAIRPGYHYIC 775 Query: 861 LQSLTGEVLAHASLFVHVAI 880 L++ + L ++FV++ + Sbjct: 776 LRNERNQPLMLPAVFVYIEV 795
>gi|130226|sp|P10686|PIG1_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) Length = 1290 Score = 196 bits (497), Expect = 4e-50 Identities = 117/301 (38%), Positives = 173/301 (57%), Gaps = 15/301 (4%) Query: 610 KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPG-DFVNYN 668 +R ++ ELSELV C+ V F E ++ + Y ++ SF E A KY N+ G F+ YN Sbjct: 945 RRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYN 1004 Query: 669 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 728 + L+R++P R+DSSN +P W CG Q+VA+NFQTP M +N F G+CGYVL Sbjct: 1005 RLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVL 1064 Query: 729 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 788 +P+ MR+E F K S+ G+ P ++ I+++ ++ PK G G +V P+V +E+ Sbjct: 1065 QPSTMRDEA--FDPFDKSSLRGLEPCVICIEVLGARHLPK-NGRG----IVCPFVEIEVA 1117 Query: 789 GIPADCAEQRTKTVHQNGDAPIFD-ESFEFQINLPELAMVRFVVLDDDYIGDE-FIGQYT 846 G D +Q+T+ V NG P++ + F FQI+ PE A +RFVV ++D D+ F+ Q T Sbjct: 1118 GAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQAT 1177 Query: 847 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 906 P + L+TGYR VPL++ E L ASL + + I + G LS G RE A Sbjct: 1178 FPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGD-----LSPFSGTSLRERA 1232 Query: 907 S 907 S Sbjct: 1233 S 1233
Score = 188 bits (477), Expect = 7e-48 Identities = 133/438 (30%), Positives = 215/438 (49%), Gaps = 56/438 (12%) Query: 153 RSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQI 212 + + R + F + + + + W D + IDI+ IKE+R GK + F D+ Sbjct: 41 KKSQRPERKTFQVKLETRQITWS-RGADKIEGSIDIREIKEIRPGKTSRDF------DRY 93 Query: 213 SEDCAFS--------VIYGENY--ESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 262 ED AF ++YG + ++L L A S D N+W+ GL +L+ D L++ Sbjct: 94 QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLME------DTLQA 147 Query: 263 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLN---PGLKTSKIEL--------- 310 + W+ + F +D + I+ + + +N P ++ + L Sbjct: 148 ATPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDFEQRSGD 207 Query: 311 ----KFKELHKSKDKAGTEVTKEEFIEVFHELCT--RPEIYFLLVQFSSNKEFLDTKDLM 364 +F +L++S + + F+E + L T RPE+ V S ++FL Sbjct: 208 ITYGQFAQLYRSLMYSAQKTMDLPFLET-NTLRTGERPEL--CQVSLSEFQQFL------ 258 Query: 365 MFLEAEQGVAHINEEISLEIIHKY--EPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHK 422 LE + + ++ E + + +P +E +E + +D +L S + +++ + Sbjct: 259 --LEYQGELWAVDRLQVQEFMLSFLRDPLREIEEP-YFFLDELVTFLFSKENSVWNSQLD 315 Query: 423 KVC-QDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNE 481 VC + M PLSHY+I+SSHNTYL DQF S + Y R L+MGCR +ELD WDGPD Sbjct: 316 AVCPETMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGM 375 Query: 482 PVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGD 541 PVIY GHT+T++I F V+ I ++AF ASEYP+IL +E+HCSI +LGD Sbjct: 376 PVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQHFRKVLGD 435 Query: 542 KLYTTSPNVEESYLPSPD 559 L T ++ LPSP+ Sbjct: 436 TLLTKPVDIAADGLPSPN 453
>gi|130230|sp|P24135|PIG2_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV) Length = 1265 Score = 178 bits (451), Expect = 7e-45 Identities = 123/402 (30%), Positives = 187/402 (46%), Gaps = 39/402 (9%) Query: 180 DSEKAKIDIKSIKEVRTGKNT-DIFRSNGISDQISEDCAFSVIYGENY--ESLDLVANSA 236 D + +DI IKE+R GKN+ D R+ + + DC F++ YG + +L L +S Sbjct: 59 DKIEGFLDIMEIKEIRPGKNSKDFERAKAVRHK--ADCCFTIFYGTQFVLSTLSLATDSK 116 Query: 237 DVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITL------- 289 + A W++GL+ L + + +S M SW+ + +D I+L Sbjct: 117 EDAVKWLSGLKILHQ------EAMNASTPTMIESWLRKQIYSVDQTRRNSISLRELKTIL 170 Query: 290 ------CNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPE 343 + ++ +++ + K EL F++ H K E K + E Sbjct: 171 PLVNFKVSGIKFLKDKLVEIGAQKDELSFEQFHLFYKKLMFEQQK----SILDEFKKDSS 226 Query: 344 IYFLLVQFSSNKEFLDTKDLMMFLEAE------QGVAHINEEISLEIIHKYEPSKEGQEK 397 ++ L + + +D FL E Q + + E ++ I + E Sbjct: 227 VFILGNTDRPDASAVYLQDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAE---- 282 Query: 398 GWLSIDGFTNYLMSPDCYIFDPEHKKV-CQDMKQPLSHYFINSSHNTYLIEDQFRGPSDI 456 +L +D F YL S + I+D ++ V QDM PLSHY+I+SSHNTYL DQ R S Sbjct: 283 PFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESST 342 Query: 457 TGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLI 516 YIR L+ GCR +ELD WDGPD +P+IY G T T++I F V+ I +AF S +P+I Sbjct: 343 EAYIRCLRAGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVI 402 Query: 517 LCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYLPSP 558 L +E HCS+ +LGD L T LPSP Sbjct: 403 LSIEEHCSVEQQRHMAKVFKEVLGDLLLTKPTEASADQLPSP 444
Score = 148 bits (373), Expect = 8e-36 Identities = 94/268 (35%), Positives = 140/268 (52%), Gaps = 22/268 (8%) Query: 617 ELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVF 676 ELS+LV CK + + + + E+ SF E A + P D + YN++ L RV+ Sbjct: 929 ELSDLVVYCKPTS--KTKDHLENPDFREIRSFVETKADSIVRQKPVDLLRYNQKGLTRVY 986 Query: 677 PSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREE 736 P R+DSSN +P W CG Q+VA+NFQTP M +N F NG GYVL+P MR E Sbjct: 987 PKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALFSLNGRTGYVLQPESMRSE 1046 Query: 737 VSFFSANTKDSVPGVSPQ----LLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPA 792 D +P S + L +K++ ++ PK S + P+V VEI G Sbjct: 1047 -------KYDPMPPESQRKILMTLTVKVLGARHLPKLGRS-----IACPFVEVEICGAEY 1094 Query: 793 DCAEQRTKTVHQNGDAPIF---DESFEFQINLPELAMVRFVVLDDDYIGD-EFIGQYTIP 848 D + +T V+ NG +P++ E F+I P LA +RF+V ++D D F+ T P Sbjct: 1095 DSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFLVYEEDMFSDPNFLAHATYP 1154 Query: 849 FECLQTGYRHVPLQSLTGEVLAHASLFV 876 + +++G+R VPL++ E + ASL V Sbjct: 1155 IKGIKSGFRSVPLKNGYSEDIELASLLV 1182
>gi|12643487|sp|Q9QW07|PIB4_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (Phosphoinositide phospholipase C) (PLC-beta-4) (Phospholipase C-beta-4) Length = 1175 Score = 160 bits (406), Expect = 1e-39 Identities = 136/446 (30%), Positives = 206/446 (46%), Gaps = 43/446 (9%) Query: 145 EGSELKKVRSNSRIYHRYFLLDADMQS--LRWEPSKKDSEKAKID-IKSIKEVRTGKNTD 201 EG+ + S ++ L D L W+ K+ + + I SI+ K+ Sbjct: 19 EGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRLAAIPKDPK 78 Query: 202 I---FRSNGISDQISEDCAFSVIYGENYESLD---LVANSADVANIWVTGLRYLIS--YG 253 I S G S+ E V G + ++ +VA + ++ WV GLR +I Sbjct: 79 ILAALESVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPEITKQWVEGLRSIIHNFRA 138 Query: 254 KHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELK-F 312 + M + M+ ++++ +I V ++ R G KT K+ + Sbjct: 139 NNVSPMTCLKKHWMKLAFLTNTSGKIPVRSI-----------TRTFASG-KTEKVIFQAL 186 Query: 313 KEL----HKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK-EFLDTKDLMMFL 367 KEL K+ + T E+F E+ ++C R +I L + + +K ++L L+ FL Sbjct: 187 KELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFL 246 Query: 368 EAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDP 419 Q +NE + +++II YEP +E ++KG +S DGF YLMS + Sbjct: 247 NEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEELKKKGLISSDGFCRYLMSDENAPVFL 306 Query: 420 EHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGP- 478 + ++ Q+M PL+HYFI+SSHNTYL QF G S + Y + L GCR VELD WDG Sbjct: 307 DRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKG 366 Query: 479 -DNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXX 537 D EP+I G M + I+F+ VI I + AF SEYP+IL ENHCS Sbjct: 367 EDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYQMSKYCED 426 Query: 538 LLGDKLYT----TSPNVEESYLPSPD 559 L GD L + P LPSP+ Sbjct: 427 LFGDLLLKQALESHPLEPGRLLPSPN 452
>gi|1730574|sp|P51432|PIP3_MOUSE 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (Phosphoinositide phospholipase C) (PLC-beta-3) (Phospholipase C-beta-3) Length = 1234 Score = 158 bits (399), Expect = 7e-39 Identities = 103/299 (34%), Positives = 158/299 (52%), Gaps = 14/299 (4%) Query: 582 DVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQK 641 D DE+E E + + +E+S LV+ + V+FK F+ S + K Sbjct: 555 DREDEEEDEEEEETTDPKKPTTDEGTASSEVNATEEMSTLVNYVEPVKFKSFEASRKRNK 614 Query: 642 YWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVA 701 +E+ SF E A + ++P +FV YNK+ L+R++P R+DSSN PQ FW GCQ+VA Sbjct: 615 CFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVA 674 Query: 702 MNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKII 761 +NFQT L M LN G F NG GY+L+P MR F T+ V G+ L +K+I Sbjct: 675 LNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVI 734 Query: 762 SGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ-RTKTVHQNGDAPIFDES-FEF-Q 818 SGQ K V YV V++ G+P D + RT+T N P++DE F+F + Sbjct: 735 SGQFLSDKK--------VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPK 786 Query: 819 INLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVH 877 + LP LA +R ++ G +F+G +P +++GY +V L++ + L +L ++ Sbjct: 787 VVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIY 842
Score = 152 bits (384), Expect = 4e-37 Identities = 113/361 (31%), Positives = 185/361 (51%), Gaps = 33/361 (9%) Query: 186 IDIKSIKEVRTGKNTDIFRSNGISDQIS--------EDCAFSVIYGE---NYESLDLVAN 234 +DI SI++ RTG+ + + I + + E+ +V+ G N L+ +A Sbjct: 64 LDISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNFMAV 123 Query: 235 SADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFS--EIDVDNLGHITLCNA 292 D +W L L +++L +Q+ R +++ + ++ ++ V+ G I + N Sbjct: 124 QDDTVKVWSEELFKL------AMNIL--AQNASRNTFLRKAYTKLKLQVNQDGRIPVKNI 175 Query: 293 VQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFS 352 ++ ++T+ +E ++S+ E E F ++LC RP+I +L++ Sbjct: 176 LKMFSADKKRVETA-LESCGLNFNRSESIRPDEFPLEIFERFLNKLCLRPDIDKILLEIG 234 Query: 353 SN-KEFLDTKDLMMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSID 403 + K +L + LM F+ +Q +NE + + +I KYE +K+ E+ +S++ Sbjct: 235 AKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRSSQARLLIEKYETNKQFLERDQMSME 294 Query: 404 GFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRAL 463 GF+ YL + I E + DM QPLS YFINSSHNTYL Q GPS + Y +AL Sbjct: 295 GFSRYLGGEENGILPLEALDLSMDMTQPLSAYFINSSHNTYLTAGQLAGPSSVEMYRQAL 354 Query: 464 KMGCRSVELDVWDG--PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLEN 521 GCR VELDVW G P+ EP I G TMT+++ R V++ I + AF S YP+IL EN Sbjct: 355 LWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAEAAFKTSPYPVILSFEN 414 Query: 522 H 522 H Sbjct: 415 H 415
>gi|3024409|sp|Q62077|PIG1_MOUSE 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) Length = 207 Score = 90.1 bits (222), Expect = 3e-18 Identities = 45/106 (42%), Positives = 65/106 (61%), Gaps = 1/106 (0%) Query: 610 KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPG-DFVNYN 668 +R ++ ELSELV C+ V F E ++ + Y ++ SF E A KY N+ G F+ YN Sbjct: 100 RRKKIALELSELVVYCRPVPFAEEKIGTERACYRDMSSFRETKAEKYVNKAKGKKFLQYN 159 Query: 669 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLN 714 + L+R++P R+DSSN +P W CG Q+VA+NFQTP M +N Sbjct: 160 RLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMN 205
Database: Non-redundant SwissProt sequences Posted date: Mar 26, 2003 12:57 AM Number of letters in database: 44,872,980 Number of sequences in database: 122,971 Lambda K H 0.317 0.134 0.396 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 10,427,179 Number of Sequences: 122971 Number of extensions: 461400 Number of successful extensions: 1253 Number of sequences better than 1.0e-05: 8 Number of HSP's better than 0.0 without gapping: 8 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 1203 Number of HSP's gapped (non-prelim): 14 length of query: 1127 length of database: 4,702,838 effective HSP length: 104 effective length of query: 1023 effective length of database: 3,638,190 effective search space: 3721868370 effective search space used: 3721868370 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 114 (48.5 bits)
